Twelve Weeks Rest–Pause and Traditional Resistance Training: Effects on Myokines and Performance Adaptations among Recreationally Trained Men

A rest–pause (RP) technique involves performing one or more repetitions at high resistance to failure, followed by a short rest before repetitions. These techniques can affect neuromuscular conditions and fatigue changing the time between This study compared effect of 12 weeks RP traditional training (TRT) on myokines (myostatin (MSTN), follistatin (FLST) insulin-like growth factor-1 (IGF-1)) functional adaptations. The recruited 29 men ages 20 30 who had performed for least 6 months. Participants were randomly divided into three groups: RP, TRT, control; was 3 days per week weeks. methods two groups largely similar. results showed that increased IGF-1 FLST/MSTN than TRT group (% change = 19.04, % 37.71), only significant changes in ratio control (p < 0.001 p 0.02, respectively). In addition, FLST levels MSTN decreased groups, but rate 0.002 0.001, Leg press bench strength, arm thigh muscular cross-sectional area (MCSA) others, percentage body fat (PBF) significantly. strength MCSA ≤ 0.05), PBF (ES 0.43; ES 0.55; 0.09) 0.005, 0.01; Based results, significantly affects muscle hypertrophy method, which be included system increase hypertrophy.